Diethyl Malonate → N-(3,5-Difluoro-benzyl)-malonamic acid

HRID 2223258Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8](C)[C:9]([OH:11])=[O:10].C(OCC)(=O)CC(OCC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH2:8][C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

Product 1

HCID 69280030N-(3,5-Difluoro-benzyl)-malonamic acid

Procedure

N-(3,5-Difluoro-benzyl)-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl malonate.

Sources & evidence

ORD record: ord-aba219eb77a0471090b666aa9dba5229
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375099B2

Reaction notes

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