Diethyl dimethylmalonate → N-(3,5-Difluoro-benzyl)-2,2-dimethyl-malonamic acid

HRID 2223260Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8]([CH3:12])[C:9]([OH:11])=[O:10].[CH3:18]C(C)(C(OCC)=O)C(OCC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[C:8]([CH3:18])([CH3:12])[C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 15382Diethyl dimethylmalonate

HCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

Product 1

HCID 21091472N-(3,5-Difluoro-benzyl)-2,2-dimethyl-malonamic acid

Procedure

N-(3,5-Difluoro-benzyl)-2,2-dimethyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl 2,2-dimethyl-malonate.

Sources & evidence

ORD record: ord-dcc234a4c7cd427c8f29a3619fa9d9ba
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375099B2

Reaction notes

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