反应详情

10% Pd/C (2 g) was added to a solution of tert-butyl 4-oxopiperidine-1-carboxylate (20 g, 100 mmol) in methylamine (33% in ethanol, 10 mL) and the mixture was stirred at room temperature, under 60 psi of hydrogen, for 18 hours. The reaction mixture was then filtered through Arbocel® and the filtrate was concentrated in vacuo. The residue was azeotroped with dichloromethane (×3) and the dried under vacuum for 72 hours to afford the title compound as a solid in 98% yield, 21.1 g. LRMS APCI m/z 215 [M+H]+

1. filtrationThe reaction mixture was then filtered through Arbocel®
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was azeotroped with dichloromethane (×3)
4. customthe dried under vacuum for 72 hours