(Trifluoromethyl)trimethylsilane → HCID 137329875, compound

HRID 2223340Notes

Reaction equation

HRID 2223340 reaction equation
FC([Si:5]([CH3:8])([CH3:7])[CH3:6])(F)F.[Si:9]([O:16][C@H:17]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:47]=[CH2:48])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][C:39](=[O:44])[C:40]([F:43])([F:42])[F:41])[CH2:34][C@:18]12[CH3:19])[C:31]1[CH:30]=[CH:29][C:28]([O:45][CH3:46])=[CH:27][C:26]=1[CH2:25][CH2:24]3)(C(C)(C)C)([CH3:11])[CH3:10]>>[C:18]([C@H:19]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:47]=[CH2:48])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][C:39]([C:40]([F:43])([F:42])[F:41])([O:44][Si:5]([CH3:6])([CH3:7])[CH3:8])[C:40]([F:41])([F:42])[F:43])[CH2:34][C@:18]12[CH2:17][O:16][SiH:9]([CH3:11])[CH3:10])[C:31]1[CH:30]=[CH:29][C:28]([O:45][CH3:46])=[CH:27][C:26]=1[CH2:25][CH2:24]3)([CH3:20])([CH3:19])[CH3:17]

Participants

3

Reactant 2

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 12136527HCID 12136527, compound

Product 1

HCID 137329875HCID 137329875, compound

Procedure

In the reaction with (trifluoromethyl)-trimethylsilane analogously to instructions 1.1, 200 mg of alcohol 16a yields 200 mg of the column-chromatographically stable trimethylsilyl ether 17a as a light yellow, viscous mass (GC-MS: m/z theor.: 720, pract.: 720). The latter is, without the reaction with tetrabutylammonium fluoride-trihydrate being performed, used in the next stage.

Sources & evidence

ORD record
ord-7007fa98c8bd4128bf259d49ec804a35
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

Loading…