Methylamine → HCID 12137007, compound

HRID 2223349Notes

Reaction equation

HRID 2223349 reaction equation
[CH3:1][NH2:2].C(=O)([O-])[O-].[Na+].[Na+].Cl[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]1[CH2:33][C@@:31]2([CH3:32])[C@@H:27]([CH2:28][CH2:29][C@@H:30]2[OH:34])[C@@:26]2([CH:35]=[CH2:36])[C@H:17]1[C:18]1[CH:19]=[CH:20][C:21]([OH:37])=[CH:22][C:23]=1[CH2:24][CH2:25]2>>[CH3:1][NH:2][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]1[CH2:33][C@@:31]2([CH3:32])[C@@H:27]([CH2:28][CH2:29][C@@H:30]2[OH:34])[C@@:26]2([CH:35]=[CH2:36])[C@H:17]1[C:18]1[CH:19]=[CH:20][C:21]([OH:37])=[CH:22][C:23]=1[CH2:24][CH2:25]2

Participants

4

Reactant 3

HCID 6329MethylamineHCID 10340Sodium CarbonateHCID 12137006HCID 12137006, compound

Product 1

HCID 12137007HCID 12137007, compound

Procedure

In the reaction with methylamine (40% in water, 3 ml/mmol) with the addition of sodium carbonate analogously to instructions 17.2, 155 mg of product mixture 30b yields 152 mg of amine 31b as a colorless solid (GC-MS: m/z theor.: 411, pract.: 411).

Sources & evidence

ORD record
ord-350b05946bea46329b9a197d84f92ee5
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

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