Sodium Carbonate → HCID 12137009, compound

HRID 2223351Notes

Reaction equation

HRID 2223351 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[Na+].[Na+].Cl[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C@H:19]1[CH2:36][C@@:34]2([CH3:35])[C@@H:30]([CH2:31][CH2:32][C@@H:33]2[OH:37])[C@@:29]2([CH:38]=[CH2:39])[C@H:20]1[C:21]1[CH:22]=[CH:23][C:24]([OH:40])=[CH:25][C:26]=1[CH2:27][CH2:28]2>>[N:1]1([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C@H:19]2[CH2:36][C@@:34]3([CH3:35])[C@@H:30]([CH2:31][CH2:32][C@@H:33]3[OH:37])[C@@:29]3([CH:38]=[CH2:39])[C@H:20]2[C:21]2[CH:22]=[CH:23][C:24]([OH:40])=[CH:25][C:26]=2[CH2:27][CH2:28]3)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 31268PyrrolidineHCID 12137006HCID 12137006, compound

Product 1

HCID 12137009HCID 12137009, compound

Procedure

In the reaction with pyrrolidine (10 equivalents) with the addition of sodium carbonate analogously to instructions 17.2, 32 mg of mixture 30b yields 33 mg of amine 33b as a colorless foam (GC-MS: m/z theor.: 451, pract.: 451).

Sources & evidence

ORD record
ord-fe7e8b7fd5fa45258a2f95ea91b560f8
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

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