Piperidine → HCID 12137010, compound

HRID 2223352Notes

Reaction equation

HRID 2223352 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[Na+].[Na+].Cl[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C@H:20]1[CH2:37][C@@:35]2([CH3:36])[C@@H:31]([CH2:32][CH2:33][C@@H:34]2[OH:38])[C@@:30]2([CH:39]=[CH2:40])[C@H:21]1[C:22]1[CH:23]=[CH:24][C:25]([OH:41])=[CH:26][C:27]=1[CH2:28][CH2:29]2>>[N:1]1([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C@H:20]2[CH2:37][C@@:35]3([CH3:36])[C@@H:31]([CH2:32][CH2:33][C@@H:34]3[OH:38])[C@@:30]3([CH:39]=[CH2:40])[C@H:21]2[C:22]2[CH:23]=[CH:24][C:25]([OH:41])=[CH:26][C:27]=2[CH2:28][CH2:29]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 10340Sodium CarbonateHCID 12137006HCID 12137006, compound

Product 1

HCID 12137010HCID 12137010, compound

Procedure

In the reaction with piperidine (10 equivalents) with the addition of sodium carbonate analogously to instructions 17.2, 34 mg of mixture 30b yields 40 mg of amine 34b as a colorless foam (GC-MS: m/z theor.: 465, pract.: 465).

Sources & evidence

ORD record
ord-bcc5bbab28da400d8bf66eee2a366938
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

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