3,4-Dichlorophenethylamine → (s)-1-(2-Nitrophenoxy)-3-(3,4-dichlorophenylethylamino)-2-propanol

Participants

Reaction Steps

Compound 17a-S (1.05 g, 5.4 mmol) and 3,4-dichloropenylethylamine (1.02 g, 0.8 ml, 5.4 mmol) were dissolved in 25 ml ethanol and refluxed for 12 hours. Then the solvent was evaporated and the residue recrystallized from ethylacetate-petroleum ether to give the product (1.02 g, 99% yield, m.p. 73-74° C.) as a white solid.

Provenance & Evidence