反应详情

[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (1.34 g, 4.2 mmol) is dissolved in CHCl3 (3 mL) and treated with TFA (3 mL) for 2 h at 20° C. The solvent is evaporated, the residue dissolved CH2Cl2 (100 mL) and washed with 1M aqueous NaOH (2×30 mL). The organic layer is dried (Na2SO4), filtered and concentrated to provide the title compound.

1. customThe solvent is evaporated
2. dissolutionthe residue dissolved CH2Cl2 (100 mL)
3. washwashed with 1M aqueous NaOH (2×30 mL)
4. dry with materialThe organic layer is dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated