4-Amino-2-methylquinoline → 1-(3-Chloro-propyl)-3-(2-methyl-quinolin-4-yl)-urea

HRID 2223714Notes

Reaction equation

HRID 2223714 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[CH:3]=1.[Cl:13][CH2:14][CH2:15][CH2:16][N:17]=[C:18]=[O:19].ClCCNC(NC1C2C(=CC=CC=2)N=C(C)C=1)=O>>[Cl:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]([NH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[CH:3]=1)=[O:19]

Participants

4

Reactant 3

HCID 811164-Amino-2-methylquinolineHCID 166752Propane, 1-chloro-3-isocyanato-HCID 23443661-(2-Chloroethyl)-3-(2-methylquinolin-4-yl)urea

Product 1

HCID 226433331-(3-Chloro-propyl)-3-(2-methyl-quinolin-4-yl)-urea

Procedure

The title compound is prepared from 4-amino-2-methylquinoline and 3-chloropropylisocyanate by the method used in the preparation of Example 1A, 1-(2-chloroethyl)-3-(2-methyl-quinol-4-yl)-urea.

Sources & evidence

ORD record
ord-b1407bc43b3649fb81cf498fb676d190
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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