4-Benzyl-4-piperidinol → 1-[3-(4-Benzyl-4-hydroxy-piperidin-1-yl)-propyl]-3-(2-methyl-quinolin-4-yl)-urea

HRID 2223715Notes

Reaction equation

HRID 2223715 reaction equation
[OH:1][C:2]1([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[CH2:16][CH2:17][CH2:18][NH:19][C:20]([NH:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:26]=[C:25]([CH3:33])[CH:24]=1)=[O:21].OC1(C2C=CC(C)=CC=2)CCN(CCNC(NC2C3C(=CC=CC=3)N=C(C)C=2)=O)CC1>>[CH2:8]([C:2]1([OH:1])[CH2:7][CH2:6][N:5]([CH2:16][CH2:17][CH2:18][NH:19][C:20]([NH:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[C:25]([CH3:33])[CH:24]=2)=[O:21])[CH2:4][CH2:3]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 981524-Benzyl-4-piperidinolHCID 179565681-[2-(4-Hydroxy-4-p-tolyl-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-ureaHCID 226433331-(3-Chloro-propyl)-3-(2-methyl-quinolin-4-yl)-urea

Product 1

HCID 179564571-[3-(4-Benzyl-4-hydroxy-piperidin-1-yl)-propyl]-3-(2-methyl-quinolin-4-yl)-urea

Procedure

Prepared from 4-hydroxy-4-benzyl-piperidine and 1-(3-chloro-propyl)-3-(2-methyl-quinolin-4-yl)-urea using the method exemplified with Example 341, 1-[2-(4-hydroxy-4-p-tolyl-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea.

Sources & evidence

ORD record
ord-de6fdda66ab043ff9654ba153705c07e
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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