反应详情

温度

80 °C

A suspension of 1,3-bis-(2-methyl-quinolin-4-yl)-urea (342.4 mg, 1 mmol), valin methyl ester hydrochloride (167.6 mg, 1 mmol) and DIPEA (0.34 mL, 2 mmol) in MeOH (10 mL) is heated at 80° C. for 15 h. The solvent is evaporated and the residue is dissolved in 6N aqueous HCl (6 mL). The reaction mixture is heated at 90° C. for 12 h. Evaporation and purification by preparative HPLC provides the title compound.

1. customThe solvent is evaporated
2. dissolutionthe residue is dissolved in 6N aqueous HCl (6 mL)
3. temperatureThe reaction mixture is heated at 90° C. for 12 h
4. customEvaporation and purification by preparative HPLC