HCID 43385182, compound → HCID 17956525, compound

HRID 2223725Notes

Reaction equation

HRID 2223725 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][NH:6][C:7]([NH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12](C)[CH:11]=1)=[O:8])C>Cl>[N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:10]([NH:9][C:7](=[O:8])[NH:6][CH2:5][C:4]([OH:21])=[O:3])=[CH:11][CH:12]=1

Participants

3

Reactant 1

HCID 43385182HCID 43385182, compound

Product 1

HCID 17956525HCID 17956525, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

[3-(2-Methyl-quinolin-4-yl)-ureido]-acetic acid ethyl ester (7.2 g, 25 mmol) is suspended in 6N aqueous HCl (250 mL), and the mixture is heated at 80° C. for 15 h. The mixture is cooled, filtered from the resulting precipitate and the solid dried to provide the title compound as hydrochloride salt.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationfiltered from the resulting precipitate
  3. customthe solid dried

Sources & evidence

ORD record
ord-ff157d15e531489486eb617f453b1648
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

Loading…