Hydrochloric Acid → HCID 69217452, compound

HRID 2223729Notes

Reaction equation

HRID 2223729 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][NH:14][C:15]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:21]=[C:20]([CH3:28])[CH:19]=2)=[O:16])[CH2:8][CH2:7]1)=[O:5])C.[ClH:29]>>[ClH:29].[ClH:29].[CH3:28][C:20]1[CH:19]=[C:18]([NH:17][C:15](=[O:16])[NH:14][CH2:13][CH2:12][N:9]2[CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59715935HCID 59715935, compound

Product 1

HCID 69217452HCID 69217452, compound

Conditions

Temperature
50 °C

Procedure

1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid ethyl ester (0.9 g, 2.3 mmol) is dissolved in 6N aqueous HCl (10 mL) and the mixture is heated at 50° C. for 48 h. The reaction mixture is evaporated and the residue is dried to provide the title compound as hydrochloride salt.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue is dried

Sources & evidence

ORD record
ord-b6a322d4ec974038b923c39a0001ffc7
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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