Methyl 4-phenylpiperidine-4-carboxylate → 1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-4-phenyl-piperidine-4-carboxylic acid methyl ester

HRID 2223732Notes

Reaction equation

HRID 2223732 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([CH3:18])[CH:9]=1)=[O:6].[CH3:19][O:20][C:21]([C:23]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22]>>[CH3:19][O:20][C:21]([C:23]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:24][CH2:25][N:26]([CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:18])[CH:9]=2)=[O:6])[CH2:27][CH2:28]1)=[O:22]

Participants

3

Reactant 2

HCID 545827Methyl 4-phenylpiperidine-4-carboxylateHCID 23443661-(2-Chloroethyl)-3-(2-methylquinolin-4-yl)urea

Product 1

HCID 597159321-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-4-phenyl-piperidine-4-carboxylic acid methyl ester

Procedure

The compound is prepared from 1-(2-chloro-ethyl)-3-(2-methyl-quinolin-4-yl)-urea (Example 1A, 2.6 g, 10 mmol)) and 4-phenyl-piperidine-4-carboxylic acid methyl ester (4.38 g, 20 mmol) using the method of Example 1.

Sources & evidence

ORD record
ord-fa4b78bed0d8450a8b9926f8a081490c
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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