HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-phenylpiperidine-4-carboxylate → 1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-4-phenyl-piperidine-4-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-phenylpiperidine-4-carboxylate | HCID 545827 | — |
| Reactant | 1-(2-Chloroethyl)-3-(2-methylquinolin-4-yl)urea | HCID 2344366 | — |
| Product | 1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-4-phenyl-piperidine-4-carboxylic acid methyl ester | HCID 59715932 | — |
Reaction Steps
The compound is prepared from 1-(2-chloro-ethyl)-3-(2-methyl-quinolin-4-yl)-urea (Example 1A, 2.6 g, 10 mmol)) and 4-phenyl-piperidine-4-carboxylic acid methyl ester (4.38 g, 20 mmol) using the method of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375227B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-fa4b78bed0d8450a8b9926f8a081490c |
| Source note | uspto-grants-2008_05 |