Hydrochloric Acid → HCID 59715928, compound

HRID 2223741Notes

Reaction equation

HRID 2223741 reaction equation
[CH2:1]([C:8]1([OH:35])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]([N:26](CC3C=CC=CC=3)[CH3:27])[CH:21]=2)=[O:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO.[Pd]>[CH2:1]([C:8]1([OH:35])[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]([NH:26][CH3:27])[CH:21]=2)=[O:18])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59715934HCID 59715934, compound

Product 1

HCID 59715928HCID 59715928, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-[2-(benzyl-methyl-amino)-pyridin-4-yl]-urea (Example 434., 0.3 g, 0.65 mmol), 2N aqueous HCl (0.65 mL, 1.3 mmol) and Pd—C 10% (30 mg) in MeOH (20 mL) is stirred under hydrogen atmosphere for 96 h. The catalyst is filtered off and the reaction mixture evaporated to provide the title compound.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe reaction mixture evaporated

Sources & evidence

ORD record
ord-64df83c9597347b691daf6494df9ae85
Source dataset
uspto-grants-2008_05
Patent number
US07375227B2

Reaction notes

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