反应详情

温度

80 °C

A 200 mg portion of 6-chloro-N,N′-diphenyl-1,3,5-triazine-2,4-diamine was dissolved in 10.0 ml of acetonitrile, and 145 mg of 4-(aminomethyl)pyridine and 0.585 ml of diisopropylethylamine were added thereto and stirred overnight at 80° C. The reaction solution was cooled down to room temperature, and then mixed with water and extracted with chloroform. The organic layer was washed with 5% citric acid and saturated brine and then dried using anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure, the thus obtained residue was applied to a silica gel column chromatography and eluted with ethyl acetate:n-hexane (2:1), and then the thus obtained crude product was crystallized from ethyl acetate/n-hexane, thereby obtaining 107 mg of N,N′-diphenyl-N″-(4-pyridylmethyl)-1,3,5-triazine-2,4,6-triamine as light red crystals.

1. temperatureThe reaction solution was cooled down to room temperature
2. extractionextracted with chloroform
3. washThe organic layer was washed with 5% citric acid and saturated brine
4. customdried
5. customThe solvent was evaporated under a reduced pressure
6. washeluted with ethyl acetate:n-hexane (2:1)
7. customthe thus obtained crude product
8. customwas crystallized from ethyl acetate/n-hexane