Imidazole → HCID 23021184, compound

HRID 2223844Notes

Reaction equation

HRID 2223844 reaction equation
[CH2:1]([C:4]1([CH2:10][OH:11])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)[CH:2]=[CH2:3].N1C=CN=C1.[CH2:17]([Si:19]([CH2:23][CH3:24])([CH2:21][CH3:22])Cl)[CH3:18]>CN(C)C=O>[CH2:1]([C:4]1([CH2:10][O:11][Si:19]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:17][CH3:18])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 795ImidazoleHCID 13819ChlorotriethylsilaneHCID 20328679HCID 20328679, compound

Product 1

HCID 23021184HCID 23021184, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a solution of (1-allylcyclohexyl)methanol (1.0 g) in N,N-dimethylformamide (7 mL) were added imidazole (661 mg) and triethylchlorosilane (1.41 mL) at room temperature. After stirring the solution at room temperature for 3 hours, N,N-dimethylformamide was added thereto and it was extracted with hexane. The combined hexane layer was washed with acetonitrile and concentrated under reduced pressure to give the title compound (1.70 g). This product was subjected to the subsequent step without further purification.

Workup

  1. extractionit was extracted with hexane
  2. washThe combined hexane layer was washed with acetonitrile
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b098320540774e41bde5f8d53d0c8f40
Source dataset
uspto-grants-2008_05
Patent number
US07375115B2

Reaction notes

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