HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 2-[1-(Cyclohexylmethyl)piperidin-4-ylamino]-5-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Reactant | 5-Methyl-N-(piperidin-4-YL)pyridin-2-amine | HCID 23021048 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[1-(Cyclohexylmethyl)piperidin-4-ylamino]-5-methylpyridine | HCID 23021000 | 75.3% |
Reaction Steps
A solution of 2-(piperidin-4-ylamino)-5-methylpyridine (191 mg), diisopropylamine (202 mg) and cyclohexylmethyl bromide (212 mg) in ethanol (2 mL) was refluxed for 16 hours. To the reaction solution was added ethyl acetate, and insolubles were filtered off, and then, concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (NH silica gel, hexane:ethyl acetate=4:1) to give the title compound (216 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375115B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-92a28647c07c4764a24557189ce4a028 |
| Source note | uspto-grants-2008_05 |