反应详情

A solution of 2-(piperidin-4-ylamino)-5-methylpyridine (191 mg), diisopropylamine (202 mg) and cyclohexylmethyl bromide (212 mg) in ethanol (2 mL) was refluxed for 16 hours. To the reaction solution was added ethyl acetate, and insolubles were filtered off, and then, concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (NH silica gel, hexane:ethyl acetate=4:1) to give the title compound (216 mg).

1. filtrationwere filtered off
2. concentrationconcentrated under reduced pressure
3. customThe resulting residue was purified by silica gel chromatography (NH silica gel, hexane:ethyl acetate=4:1)