HCID 59714980, compound → HCID 59714922, compound

HRID 2223888Notes

Reaction equation

HRID 2223888 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]3([CH2:30][CH2:31][NH:32]C(=O)OC(C)(C)C)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH2:18][CH2:17]2)[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)=[O:10])=[N:6][CH:7]=1>Cl.O1CCOCC1.CO>[NH2:32][CH2:31][CH2:30][C:24]1([CH2:23][CH2:22][N:19]2[CH2:18][CH2:17][CH:16]([N:8]([C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=3)[C:9]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)=[O:10])[CH2:21][CH2:20]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 1

HCID 59714980HCID 59714980, compound

Product 1

HCID 59714922HCID 59714922, compoundYield 129.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

tert-Butyl [2-[1-[2-[4-[N-(5-methylpyridin-2-yl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]ethyl]carbamate (0.4760 g) was dissolved in a 4N hydrochloric acid/1,4-dioxane solution (10.0 mL) and methanol (5 mL). The solution was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure to give the title compound (0.5036 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a2d74cdea1b54d78acb3038bc279c670
Source dataset
uspto-grants-2008_05
Patent number
US07375115B2

Reaction notes

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