反应详情

To a solution of tert-butyl [2-[3-[4-[N-(5-metylpyridin-2-yl)-2-furancarboxamido]piperidin-1-yl]propyl]phenyl]carbamate (790 mg) in methanol (15 mL) was added a 4N hydrochloric acid/ethyl acetate solution (2.3 mL) at room temperature. The solution was stirred at room temperature for 16 hours. The solution was then concentrated under reduced pressure. Saturated aqueous sodium bicarbonate solution was added to the residue and the solution was extracted with chloroform. The extract was dried over over anhydrous sodium sulfate, and then, concentrated under reduced pressure to give the title compound (700 mg).

1. concentrationThe solution was then concentrated under reduced pressure
2. additionSaturated aqueous sodium bicarbonate solution was added to the residue
3. extractionthe solution was extracted with chloroform
4. dry with materialThe extract was dried over over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure