反应详情

To a solution of N-[1-[3-(2-aminophenyl)propyl]piperidin-4-yl]-N-(5-methylpyridin-2-yl)-2-furancarboxamide (100 mg) and cyclohexylpropionic acid (49 mg) in dichloromethane (3 mL) were added 1-hydroxybenzotriazole (42 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (60 mg) under ice cooling. The solution was stirred at room temperature for 64 hours. Chloroform was then added to the solution and the solution was washed in turn with water and saturated aqueous sodium bicarbonate solution. The solution was dried over anhydrous sodium sulfate, and then, concentrated under reduced pressure. The residue was purified by chromatography (NH silica gel, hexane:ethyl acetate=1:2) to give the title compound (120 mg).

1. washthe solution was washed in turn with water and saturated aqueous sodium bicarbonate solution
2. dry with materialThe solution was dried over anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by chromatography (NH silica gel, hexane:ethyl acetate=1:2)