反应详情

To a solution of tert-butyl 4-[1-(1-methylpiperidin-4-yl)-1-phenylethyl]piperazine-1-carboxylate 0.16 g (0.41 mmol) in methylene chloride (20 ml) was added trifluoroacetic acid (5 ml) and resulting mixture stirred at room temperature for 2 hours. The reaction mixture was concentrated, dissolved in methylene chloride and washed with saturated sodium bicarbonate and brine. The methylene chloride solution was dried over sodium sulfate and concentrated to give 0.1 g (yield 82%) of desired product.

1. customresulting mixture
2. concentrationThe reaction mixture was concentrated
3. dissolutiondissolved in methylene chloride
4. washwashed with saturated sodium bicarbonate and brine
5. dry with materialThe methylene chloride solution was dried over sodium sulfate
6. concentrationconcentrated