5-(Bromomethyl)-2-(trifluoromethyl)pyridine → 7-Chloro-8-(4-chlorophenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)methyl-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

HRID 2224257Notes

Reaction equation

HRID 2224257 reaction equation
[Cl:1][C:2]1[CH:7]=[N:6][N:5]2[C:8](=[O:11])[NH:9][N:10]=[C:4]2[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1.Br[CH2:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[N:25][CH:26]=1>>[Cl:1][C:2]1[CH:7]=[N:6][N:5]2[C:8](=[O:11])[N:9]([CH2:20][C:21]3[CH:26]=[N:25][C:24]([C:27]([F:30])([F:28])[F:29])=[CH:23][CH:22]=3)[N:10]=[C:4]2[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 144051255-(Bromomethyl)-2-(trifluoromethyl)pyridineHCID 597168567-chloro-8-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Product 1

HCID 597169037-Chloro-8-(4-chlorophenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)methyl-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Procedure

Using the procedure described in Example 274, 7-chloro-8-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one prepared as described in Example 273 was reacted with 5-(bromomethyl)-2-(trifluoromethyl)pyridine to give the title compound, 7-chloro-8-(4-chlorophenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)methyl-[1,2,4]triazolo[4,3-b]pyridazin-3 (2H)-one.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-35c77670b0cd44f4ba0e70207cb4a57a
Source dataset
uspto-grants-2008_05
Patent number
US07378418B2

Reaction notes

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