Phosphorus oxychloride → HCID 59716637, compound

HRID 2224260Notes

Reaction equation

HRID 2224260 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][NH:11][C:10](=O)[C:9]=2[C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:10]1[N:11]=[N:12][CH:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[C:9]=1[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 59716568HCID 59716568, compound

Product 1

HCID 59716637HCID 59716637, compound

Procedure

5-(4-Fluorophenyl)-4-(pyridin-4-yl)pyridazin-3(2H)-one was reacted with POCl3 using procedures analogous to those described in Example 273C to give the title compound, 3-chloro-5-(4-fluorophenyl)4-(pyridin-4-yl)pyridazine. LC/MS (method A): RT=1.43 min, (M+H)+=286.

Sources & evidence

ORD record
ord-fd2aaa94c4a74f65bc9123e11d872183
Source dataset
uspto-grants-2008_05
Patent number
US07378418B2

Reaction notes

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