反应详情

To a suspension of 2-benzyl-4-chloro-5-methoxypyridazin-3(2H)-one (22.2 g, 87.47 mmol) in water (150.0 mL), potassium hydroxide (5.89 g) was added and the mixture was heated to reflux. After 3 h, the mixture was then cooled to room temperature and 6N aqueous hydrochloric acid was added and the pH of the solution was adjusted to 3.0. The precipitate was filtered, washed with water and dried under reduced pressure to give the title compound, 2-benzyl-4-chloro-5-hydroxypyridazin-3(2H)-one (20.45 g) as a white solid. HPLC: 2.40 min.

1. additionwas added
2. temperaturethe mixture was heated to reflux
3. filtrationThe precipitate was filtered
4. washwashed with water
5. customdried under reduced pressure