HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine → 6-Acetyl-3-fluoro-5,6-dihydro-2-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,2-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine | HCID 2795363 | — |
| Reactant | 6-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine | HCID 69291197 | — |
| Reactant | 6-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine | HCID 74393412 | — |
| Product | 6-Acetyl-3-fluoro-5,6-dihydro-2-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,2-c][1]benzazocine | HCID 69291112 | 72.2% |
Reaction Steps
Compound 5B (20.5 mg, 72.2%) was prepared from 1D (20.0 mg, 0.066 mmol) and 5A (28.7 mg, 0.099 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.336 min; LCMS Found: (M+H)+=431.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-bd7cd6378d434181a451f9c839b5f0b0 |
| Source note | uspto-grants-2008_05 |