2-Chloronicotinic acid → (2-Chloropyridin-3-yl)methanol

HRID 2224314Notes

Reaction equation

HRID 2224314 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].ClC1C(CO)=CC(F)=C(Cl)N=1>>[Cl:1][C:2]1[C:3]([CH2:4][OH:5])=[CH:7][CH:8]=[CH:9][N:10]=1

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanol

Product 1

HCID 2763647(2-Chloropyridin-3-yl)methanolYield 44%

Procedure

Compound 12A (0.20 g, 44%) was prepared from 2-chloro-nicotinic acid (0.5 g, 3.17 mmol) using a procedure similar to the synthesis of 1A. HPLC Rt=0.77 min.

Sources & evidence

ORD record
ord-04544bfbaa804f76a00282c19520cb99
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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