(2-Chloropyridin-3-yl)methanol → 3-(Bromomethyl)-2-chloropyridine

HRID 2224315Notes

Reaction equation

HRID 2224315 reaction equation
ClC1C(CO)=CC=CN=1.[Br:10][CH2:11][C:12]1[C:13]([Cl:20])=[N:14][C:15](Cl)=[C:16](F)[CH:17]=1>>[Br:10][CH2:11][C:12]1[C:13]([Cl:20])=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 2763647(2-Chloropyridin-3-yl)methanolHCID 597175733-(Bromomethyl)-2,6-dichloro-5-fluoropyridine

Product 1

HCID 189310283-(Bromomethyl)-2-chloropyridineYield 78%

Procedure

Compound 12B (0.22 g, 78%) was prepared from 12A (0.20 g, 1.39 mmol) using a procedure similar to the synthesis of 1B. HPLC Rt=1.94 min.

Sources & evidence

ORD record
ord-14a4f5c969c4475ebf6f1875d117b296
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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