2,6-Dichloronicotinic acid → (2,6-Dichloropyridin-3-yl)methanol

HRID 2224317Notes

Reaction equation

HRID 2224317 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].ClC1C(CO)=CC(F)=C(Cl)N=1>>[Cl:1][C:2]1[C:3]([CH2:4][OH:5])=[CH:7][CH:8]=[C:9]([Cl:11])[N:10]=1

Participants

3

Reactant 2

HCID 8540472,6-Dichloronicotinic acidHCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanol

Product 1

HCID 12259932(2,6-Dichloropyridin-3-yl)methanolYield 89%

Procedure

Compound 13A (0.82 g, 89%) was prepared from 2,6-dichloro-nicotinic acid (1.0 g, 5.2 mmol) using a procedure similar to the synthesis of 1A. HPLC Rt=1.39 min.

Sources & evidence

ORD record
ord-5a582b314f9a43f8b9766d6dca217e8e
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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