3-(Bromomethyl)-2,6-dichloropyridine → 6-Acetyl-2-chloro-5,6-dihydropyrido[3,2-c][1]benzazocine

HRID 2224319Notes

Reaction equation

HRID 2224319 reaction equation
BrCC1C(Cl)=NC(Cl)=CC=1.[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18][C:17]2[N:26]=[C:27]([Cl:31])[C:28](F)=[CH:29][C:16]=2[CH2:15]1)(=[O:13])[CH3:12]>>[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18][C:17]2[N:26]=[C:27]([Cl:31])[CH:28]=[CH:29][C:16]=2[CH2:15]1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 122653943-(Bromomethyl)-2,6-dichloropyridineHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 728201796-Acetyl-2-chloro-5,6-dihydropyrido[3,2-c][1]benzazocine

Procedure

Compound 13C was prepared from bb and 13B by a route analogous to that used for the preparation of 1D. HPLC Rt=2.493 min; LCMS Found: (M+H)+=285.

Sources & evidence

ORD record
ord-2019b49b2cda4e10ac154d57f8a64515
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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