(2,6-Dichloro-5-fluoropyridin-3-yl)methanol → 3-Iodo-4-pyridinemethanol

HRID 2224325Notes

Reaction equation

HRID 2224325 reaction equation
Cl.[I:2][C:3]1[CH:11]=[N:10][CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].ClC1C(CO)=CC(F)=C(Cl)N=1>>[I:2][C:3]1[CH:11]=[N:10][CH:9]=[CH:8][C:4]=1[CH2:5][OH:6]

Participants

3

Reactant 2

HCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanolHCID 689780203-Iodo-isonicotinic acid hydrochloride

Product 1

HCID 231066213-Iodo-4-pyridinemethanolYield 33%

Procedure

Compound 24A (142 mg, 33%) was prepared from 3-iodo-isonicotinic acid hydrochloride (522 mg, 1.83 mmol) ) using a procedure similar to the synthesis of 1A. HPLC Rt=0.34 min.

Sources & evidence

ORD record
ord-b36966b807584a1eb391bd21a898a2e5
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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