3-Iodo-4-pyridinemethanol → 6-Acetyl-5,6-dihydropyrido[4,3-c][1]benzazocine

HRID 2224327Notes

Reaction equation

HRID 2224327 reaction equation
I[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.[C:10]([N:13]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[CH:17]C2N=C(Cl)C(F)=CC=2C1)(=[O:12])[CH3:11]>>[C:10]([N:13]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[CH:17][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[CH2:8]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 231066213-Iodo-4-pyridinemethanolHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 692892866-Acetyl-5,6-dihydropyrido[4,3-c][1]benzazocine

Procedure

Compound 24C was prepared from 24A and bb in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=1.383 min; LCMS Found: (M+H)+=251.

Sources & evidence

ORD record
ord-2c90e016997b4176b7272849474422c7
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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