(2,6-Dichloro-5-fluoropyridin-3-yl)methanol → (2-Chloro-5-iodo-pyridin-4-yl)-methanol

HRID 2224329Notes

Reaction equation

HRID 2224329 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([I:11])=[CH:9][N:10]=1)[C:5](O)=[O:6].ClC1C(CO)=CC(F)=C(Cl)N=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[C:8]([I:11])=[CH:9][N:10]=1

Participants

3

Reactant 2

HCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanolHCID 597175682-Chloro-5-iodo-isonicotinic acid

Product 1

HCID 59717559(2-Chloro-5-iodo-pyridin-4-yl)-methanolYield 51.3%

Procedure

Compound 25C (0.38 g, 51%) was prepared from 25B (0.78 g, 2.75 mmol) using a procedure similar to the synthesis of 1A. HPLC Rt=1.74 min.

Sources & evidence

ORD record
ord-ffa05fc280f543b3a27f10d80d3b9fe6
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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