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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2224329Generated: October 29, 2026

(2,6-Dichloro-5-fluoropyridin-3-yl)methanol → (2-Chloro-5-iodo-pyridin-4-yl)-methanol

https://huagongshe.com/reaction/2224329

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2,6-Dichloro-5-fluoropyridin-3-yl)methanolHCID 23114857—
Reactant2-Chloro-5-iodo-isonicotinic acidHCID 59717568—
Product(2-Chloro-5-iodo-pyridin-4-yl)-methanolHCID 5971755951.3%

Reaction Steps

Compound 25C (0.38 g, 51%) was prepared from 25B (0.78 g, 2.75 mmol) using a procedure similar to the synthesis of 1A. HPLC Rt=1.74 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07378426B2
Source datasetuspto-grants-2008_05
ORD IDord-ffa05fc280f543b3a27f10d80d3b9fe6
Source noteuspto-grants-2008_05