(2-Chloro-5-iodo-pyridin-4-yl)-methanol → 4-Bromomethyl-2-chloro-5-iodo-pyridine

HRID 2224330Notes

Reaction equation

HRID 2224330 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[C:5]([I:10])=[CH:4][N:3]=1.[Br:11]CC1C(Cl)=NC(Cl)=C(F)C=1>>[Br:11][CH2:8][C:6]1[C:5]([I:10])=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 59717559(2-Chloro-5-iodo-pyridin-4-yl)-methanolHCID 597175733-(Bromomethyl)-2,6-dichloro-5-fluoropyridine

Product 1

HCID 597175634-Bromomethyl-2-chloro-5-iodo-pyridineYield 60%

Procedure

Compound 25D (0.28 g, 60%) was prepared from 25C (0.38 g, 1.4 mmol) using a procedure similar to the synthesis of 1B. HPLC Rt=2.72 min.

Sources & evidence

ORD record
ord-e4f22f5af1d14b2c9dfb3d19fe25a480
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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