4-Bromomethyl-2-chloro-5-iodo-pyridine → 6-Acetyl-3-chloro-5,6-dihydropyrido[4,3-c][1]benzazocine

HRID 2224331Notes

Reaction equation

HRID 2224331 reaction equation
Br[CH2:2][C:3]1[C:8](I)=[CH:7][N:6]=[C:5]([Cl:10])[CH:4]=1.[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18]C2N=C(Cl)C(F)=CC=2C1)(=[O:13])[CH3:12]>>[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18][C:8]2[CH:7]=[N:6][C:5]([Cl:10])=[CH:4][C:3]=2[CH2:2]1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 597175634-Bromomethyl-2-chloro-5-iodo-pyridineHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 723667836-Acetyl-3-chloro-5,6-dihydropyrido[4,3-c][1]benzazocine

Procedure

Compound 25E was prepared from 25D and bb in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=2.506 min; LCMS Found: (M+H)+=285.

Sources & evidence

ORD record
ord-edd44406225d4ae680054aa315dbe60b
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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