2-Acetylphenylboronic acid → HCID 69292962, compound

HRID 2224334Notes

Reaction equation

HRID 2224334 reaction equation
[C:1]([N:4]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH:9]=[CH:8][C:7]2[CH:16]=[N:17][C:18](Cl)=[CH:19][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].[C:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1B(O)O)(=[O:23])[CH3:22].C(N1C2C=CC=CC=2C=CC2N=C(C3C=NC(OC)=CC=3)C(F)=CC=2C1)(=O)C>>[C:1]([N:4]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH:9]=[CH:8][C:7]2[CH:16]=[N:17][C:18]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[C:21](=[O:23])[CH3:22])=[CH:19][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 27343092-Acetylphenylboronic acidHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocineHCID 723667836-Acetyl-3-chloro-5,6-dihydropyrido[4,3-c][1]benzazocine

Product 1

HCID 69292962HCID 69292962, compoundYield 70%

Procedure

The title compound (12.0 mg, 70%) was prepared from 25E (16.0 mg, 0.055 mmol) and 2-acetylphenylboronic acid (13.8 mg, 0.079 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.05 min; LCMS Found: (M+H)+=367.

Sources & evidence

ORD record
ord-a32db028f5964bb38916862d72556325
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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