4-Bromomethyl-2-chloro-5-iodo-pyridine → 6-Acetyl-3,9-dichloro-5,6-dihydropyrido[4,3-c][1]benzazocine

HRID 2224335Notes

Reaction equation

HRID 2224335 reaction equation
Br[CH2:2][C:3]1[C:8](I)=[CH:7][N:6]=[C:5]([Cl:10])[CH:4]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[C:14]([CH:22]=[CH2:23])[CH:13]=1.C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[C:19]([N:18]1[C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][C:14]=2[CH:22]=[CH:23][C:8]2[CH:7]=[N:6][C:5]([Cl:10])=[CH:4][C:3]=2[CH2:2]1)(=[O:21])[CH3:20]

Participants

4

Reactant 3

HCID 597175634-Bromomethyl-2-chloro-5-iodo-pyridineHCID 59717611N-(4-chloro-2-vinyl-phenyl)-acetamideHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 723667806-Acetyl-3,9-dichloro-5,6-dihydropyrido[4,3-c][1]benzazocine

Procedure

The title compound was prepared from 25D and 9B in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=2.836 min; LCMS Found: (M+H)+=319.

Sources & evidence

ORD record
ord-dd9c3585fc1846f7b798fe1dff217283
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

Loading…