4,6-Dichloronicotinic acid → (4,6-Dichloropyridin-3-yl)methanol

HRID 2224336Notes

Reaction equation

HRID 2224336 reaction equation
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[CH:6][N:5]=[C:4]([Cl:11])[CH:3]=1.ClC1C(CO)=CC(F)=C(Cl)N=1>>[Cl:1][C:2]1[CH:3]=[C:4]([Cl:11])[N:5]=[CH:6][C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 2

HCID 8171584,6-Dichloronicotinic acidHCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanol

Product 1

HCID 2762727(4,6-Dichloropyridin-3-yl)methanolYield 60%

Procedure

Compound 41A (2.5 g, 60%) was prepared from 4,6-dichloro-nicotinic acid (4.5 g, 23.4 mmol) using a procedure similar to the synthesis of 1A.

Sources & evidence

ORD record
ord-366862b48ec549de8844653d1791a9bd
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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