2,4-Dichloro-5-(chloromethyl)pyridine → N-(4,6-dichloro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamide

HRID 2224338Notes

Reaction equation

HRID 2224338 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH2:9]Cl)=[CH:4][N:3]=1.ClC1C(C[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH:29]=[CH2:30])[C:20](=[O:22])[CH3:21])=CC(F)=C(Cl)N=1>>[Cl:8][C:6]1[CH:7]=[C:2]([Cl:1])[N:3]=[CH:4][C:5]=1[CH2:9][N:19]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH:29]=[CH2:30])[C:20](=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 27627282,4-Dichloro-5-(chloromethyl)pyridineHCID 59717570N-(2,6-dichloro-5-fluoro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamide

Product 1

HCID 59717600N-(4,6-dichloro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamideYield 82%

Procedure

Compound 41C (210 mg, 82%) was prepared from 41B (157 mg, 0.8 mmol) and bb (129 mg, 0.8 mmol) using a procedure similar to the synthesis of 1C.

Sources & evidence

ORD record
ord-01d1c66d3ffc4873ae36f92b1e6baa77
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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