N-(4,6-dichloro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamide → 1-(3-chloro-12H-2,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone

HRID 2224339Notes

Reaction equation

HRID 2224339 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][C:3]=1[CH2:9][N:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH:20]=[CH2:21])[C:11](=[O:13])[CH3:12].C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[Cl:8][C:6]1[N:5]=[CH:4][C:3]2[CH2:9][N:10]([C:11](=[O:13])[CH3:12])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH:20]=[CH:21][C:2]=2[CH:7]=1

Participants

3

Reactant 2

HCID 59717600N-(4,6-dichloro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamideHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 723667771-(3-chloro-12H-2,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanoneYield 63.2%

Procedure

Compound 41D (117 mg, 63%) was prepared from 41C (210 mg, 0.65 mmol) using a procedure similar to the synthesis of 1D. HPLC Rt=2.519 min; LCMS Found: (M+H)+=285.

Sources & evidence

ORD record
ord-fe97389afd714fc6b5822833d3da90e2
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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