Phenylboronic Acid → HCID 69293038, compound

HRID 2224340Notes

Reaction equation

HRID 2224340 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[CH2:12][N:11]([C:13](=[O:15])[CH3:14])[C:10]3[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:20]=1.[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(N1C2C=CC=CC=2C=CC2N=C(C3C=NC(OC)=CC=3)C(F)=CC=2C1)(=O)C>>[C:13]([N:11]1[C:10]2[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=2[CH:8]=[CH:7][C:6]2[CH:20]=[C:2]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:3]=[CH:4][C:5]=2[CH2:12]1)(=[O:15])[CH3:14]

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocineHCID 723667771-(3-chloro-12H-2,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone

Product 1

HCID 69293038HCID 69293038, compoundYield 47%

Procedure

Compound 41E (10.7 mg, 47%) was prepared from 41D (20 mg, 0.070 mmol) and phenylboronic acid (12.8 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.286 min; LCMS Found: (M+H)+=327.

Sources & evidence

ORD record
ord-71db9ea5ab054aa2a60f29bcf5b79a21
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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