HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 11-Acetyl-11,12-dihydro-3-(6-methoxy-3-pyridinyl)pyrido[3,4-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 16217714 | — |
| Reactant | 6-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine | HCID 69291197 | — |
| Reactant | 1-(3-chloro-12H-2,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone | HCID 72366777 | — |
| Product | 11-Acetyl-11,12-dihydro-3-(6-methoxy-3-pyridinyl)pyrido[3,4-c][1]benzazocine | HCID 69291333 | 65% |
Reaction Steps
The title compound (16.3 mg, 65%) was prepared from 41D (20 mg, 0.07 mmol) and 2A (24.7 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.453 min; LCMS Found: (M+H)+=358.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-005c372240634cb5bd491707d01c2883 |
| Source note | uspto-grants-2008_05 |