3-Iodopicolinic acid → (3-Iodopyridin-2-yl)methanol

HRID 2224345Notes

Reaction equation

HRID 2224345 reaction equation
[I:1][C:2]1[C:3]([C:8](O)=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.ClC1C(CO)=CC(F)=C(Cl)N=1>>[I:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 112536923-Iodopicolinic acidHCID 23114857(2,6-Dichloro-5-fluoropyridin-3-yl)methanol

Product 1

HCID 59717577(3-Iodopyridin-2-yl)methanolYield 10.6%

Procedure

Compound 51A (10 mg, 10%) was prepared from 3-iodo-pyridine-2-carboxylic acid (100 mg, 0.4 mmol) ) using a procedure similar to the synthesis of 1A. HPLC Rt=0.3 min

Sources & evidence

ORD record
ord-d37374855e164e74b6f18014674ccef6
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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