N-(3-iodo-pyridin-2-ylmethyl)-N-(2-vinyl-phenyl)-acetamide → 11-Acetyl-11,12-dihydropyrido[2,3-c][1]benzazocine

HRID 2224347Notes

Reaction equation

HRID 2224347 reaction equation
I[C:2]1[C:3]([CH2:8][N:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH:19]=[CH2:20])[C:10](=[O:12])[CH3:11])=[N:4][CH:5]=[CH:6][CH:7]=1.C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[C:10]([N:9]1[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH:19]=[CH:20][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[CH2:8]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 59717574N-(3-iodo-pyridin-2-ylmethyl)-N-(2-vinyl-phenyl)-acetamideHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 6929101911-Acetyl-11,12-dihydropyrido[2,3-c][1]benzazocineYield 55%

Procedure

Compound 51D (3.1 mg, 55%) was prepared from 51C (8.5 mg, 0.0225 mmol) by a route analogous to that used for the preparation of 1D. HPLC Rt=1.503 min; LCMS Found: (M+H)+=251.

Sources & evidence

ORD record
ord-50a68d039b4049aba98c4fedadcb2224
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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