HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butyl nitrite → 3,5-Dibromo-2-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | Wisteria sinensis, ext. | HCID 522994 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,5-Dibromo-2-methylpyridine | HCID 619705 | 42.5% |
Reaction Steps
To a solution of 3,5-dibromo-6-methyl-pyridin-2-ylamine (2.0 g, 7.5 mmol) in THF (75 mL) was added t-butylnitrite (1.5 mL, 12.6 mmol) and the reaction was heated to reflux for 2 hours. The reaction was concentrated in vacuo and purified by flash chromatography (SiO2, CH2Cl2) to give 52A (0.8 g 42%). HPLC Rt=2.77 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-047d0d3583784aa993554947dd91ce01 |
| Source note | uspto-grants-2008_05 |