反应详情

To a solution of 3,5-dibromo-6-methyl-pyridin-2-ylamine (2.0 g, 7.5 mmol) in THF (75 mL) was added t-butylnitrite (1.5 mL, 12.6 mmol) and the reaction was heated to reflux for 2 hours. The reaction was concentrated in vacuo and purified by flash chromatography (SiO2, CH2Cl2) to give 52A (0.8 g 42%). HPLC Rt=2.77 min.

1. temperaturethe reaction was heated
2. temperatureto reflux for 2 hours
3. concentrationThe reaction was concentrated in vacuo
4. custompurified by flash chromatography (SiO2, CH2Cl2)